A novel three-component [5 + 1] heterocyclization leading to 2-azafluorenone synthesis and its polyfunctionalizations.
نویسندگان
چکیده
An efficient methodology for the synthesis of new and highly functionalized 2-azafluorenones via a three-component domino reaction involving C1-aryl acylation, C3-thiolation, and C4-cyanation has been developed. This domino reaction enables successful assembly of three new sigma bonds including a C-S bond and a C-N bond in a one-pot operation. Features of this strategy include the mild condition, convenient one-pot operation, and short reaction periods (15-30 min).
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 15 شماره
صفحات -
تاریخ انتشار 2013